The mantra of 'Faster, Better, Cheaper' has to a large degree been interpreted as using Commercial Off-the-Shelf (COTS) components and/or circuit boards. One of the first space applications to actually use COTS in space along with radiation performance requirements was the Expedite the Processing of Experiments to Space Station (EXPRESS) Rack program, for the International Space Station (ISS). In order to meet the performance, cost and schedule targets, military grade Versa Module Eurocard (VME) was selected as the baseline design for the main computer, the Rack Interface Controller (RIC). VME was chosen as the computer backplane because of the large variety of military grade boards available, which were designed to meet the military environmental specifications (thermal, shock, vibration, etc.). These boards also have a paper pedigree in regards to components. Since these boards exceeded most ISS environmental requirements, it was reasoned using COTS mid-grade VME boards, as opposed to designing custom boards could save significant time and money. It was recognized up front the radiation environment of ISS, while benign compared to many space flight applications, would be the main challenge to using COTS. Thus in addition to selecting vendors on how well their boards met the usual performance and environmental specifications, the board's parts lists were reviewed on how well they would perform in the ISS radiation environment. However, issues with verifying that the available radiation test data was applicable to the actual part used, vendor part design changes and the fact most parts did not have valid test data soon complicated board and part selection in regards to radiation.